Abemaciclib: A multi-functional radiation modifier
نویسندگان
چکیده
منابع مشابه
Disulfiram as a radiation modifier.
The radiation modifying effect and toxicity of tetraethylthiuram disulfide (disulfiram) have been studied. Disulfiram (DSM) inhibits aldehyde dehydrogenase, dopamine-beta-oxygenase, microsomal mixed-function oxidases and cytochrome P-450 enzymes. It is widely used for aversion therapy in alcoholism. Disulfiram also inhibits tumor formation by several known carcinogens. A biphasic toxicity patte...
متن کاملCerenkov radiation: a multi-functional approach for biological sciences
*Correspondence: Zhen Cheng, Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program, Canary Center at Stanford for Cancer Early Detection, 1201 Welch Road, Lucas Expansion, P095 Stanford University, Stanford, CA 94305, USA e-mail: [email protected] Cerenkov radiation (CR) has been used in various biological research fields, which has aroused lots of attention in rece...
متن کاملImprovement of Cement Properties Using a Single Multi-functional Polymer
Cementing of the casing pipes inside the wellbore is considered as one of the most expensive and difficult operations during the well construction process. A low quality cementing job leads to further repair operations, which are usually costly and time-consuming to conduct. Polymer cements are being used for decades in the oil and gas industry due to their improved properties such as sedimenta...
متن کاملSingle-Agent Abemaciclib Active in Breast Cancer.
According to results from a phase II study, abemaciclib shows single-agent activity in women with metastatic HER2-negative, ER-positive breast cancer whose disease has progressed on endocrine therapy and chemotherapy. The objective response rate to this investigational CDK4/6 inhibitor was 19.7%, with 28.2% of responses lasting at least a year.
متن کاملPredicting genetic modifier loci using functional gene networks.
Most phenotypes are genetically complex, with contributions from mutations in many different genes. Mutations in more than one gene can combine synergistically to cause phenotypic change, and systematic studies in model organisms show that these genetic interactions are pervasive. However, in human association studies such nonadditive genetic interactions are very difficult to identify because ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2019
ISSN: 1949-2553
DOI: 10.18632/oncotarget.26652